Key Publications

Clinical

Topical Administration of a Connexin43-Based Peptide Augments Healing of Chronic Neuropathic Diabetic Foot Ulcers: A Multicenter, Randomized Trial

Journal: Wound Repair and Regeneration (2015)

Download

The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial

Journal: Journal of Investigative Dermatology (2015)

Download

A Multicenter Randomized Controlled Trial Evaluating a Cx43-Mimetic Peptide in Cutaneous Scarring

Journal: Journal of Investigative Dermatology (2017)

Download

Preclinical

Connexin43 Carboxyl-Terminal Peptides Reduce Scar Progenitor and Promote Regenerative Healing Following Skin Wounding

Journal: Regenerative Medicine (2009)

Download

A Synthetic Connexin43 Mimetic Peptide Augments Corneal Wound Healing

Journal: Experimental Eye Research (2013)

Download

Impact of the Controlled Release of a Connexin43 Peptide on Corneal Wound Closure in an STZ Model of Type I Diabetes

Journal: PLoS ONE (2014)

Download

Cardiac to Cancer: Connecting Connexins to Clinical Opportunity

Journal: FEBS Letters (2014)

Download

Targeting the Tight Junction Protein, Zonula Occludens-1, with the Connexin43 Mimetic Peptide, αCT1, Reduces VEGF-Dependent RPE Pathophysiology

Journal: Journal of Molecular Medicine (2017)

Download

Connexin43-Based Therapeutics for Dermal Wound Healing

Journal: International Journal of Molecular Sciences (2018)

Download

Mechanism of Action

Zonula Occludens-1 Alters Connexin43 Gap Junction Size and Organization by Influencing Channel Accretion

Journal: Molecular Biology of the Cell (2005)

Download

The Unstoppable Connexin43 Carboxyl-Terminus – New Roles in Gap Junction Organization and Wound Healing

Journal: Annals New York Academy of Sciences (2006)

Download

Novel Therapies for Scar Reduction and Regenerative Healing of Skin Wounds

Journal: Trends in Biotechnology (2008)

Download

Connexin43 connexon to gap junction transition is regulated by zonula occludens-1

Journal: Molecular Biology of the Cell (2011)

Download

The Connexin43 Carboxyl Terminus and Cardiac Gap Junction Organization

Journal: Biochimica et Biophysica Acta (2012)

Download